Modern skincare science continues to evolve from its empirical roots. Plant derivatives became popular in Victorian times, but other nineteenth century discoveries such as glycerol and petrolatum became widespread only in the mid-20th century. Animal extracts used as active ingredients emulated substances found in the skin – including collagen (bovine), keratin, fibronectin, and hyaluronic acid – were widely introduced in the 1970s. However, with the ‘mad cow disease’ incidents of the late 1980s, the industry eliminated newly found animal sources. The introduction of vitaminic components and alpha hydroxy and retinoic acid-derived substances followed. Concentrations were limited to avoid avoid regulatory classification as drugs.

miRcutis RNA-derived active ingredients represent the third and latest stage in skincare: treatment by bioactive constituents. Unlike chemical agents of the past which rely on uncertain reactions and side effects, RPM is based on gene expression in the skin. miRcutis active ingredients rely on microRNAs which are found naturally within the skin (endogenous) and regulate multiple key factors associated with skin phenotypes and conditions without restructuring of the epidermis.